Tuesday, January 30, 2007

Comparative Genomic Hybridization - huh?

In a press release by the Sher Institute, they discuss comparative genomic hybridization (CGH) - a method in which DNA derived from a small egg chromosomal structure known as the first Polar body (PB-1), located immediately below the egg surface is tested. This testing aims to identify and then selectively fertilize only those eggs that are chromosomally normal and were thus deemed highly likely to be capable of developing into chromosomally normal embryos.

The results they report are good - a 74% live birth rate from a single cycle. In addition, they only transferred a maximum of two embryos, significantly reducing the risk of higher order multiples.

The same press release also mentions egg freezing using CGH and vitrification (a new method of rapid freezing of the ova, without causing damage to them) to freeze top-quality eggs for future use. 95% of the eggs frozen in the study thawed successfuly and 60% developed into viable embryos.

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