Thursday, February 08, 2007

PCOS - Clomid or Metformin?

Here's a quick summary of this article.

In an article coming out today in the New England Journal of Medicine (article abstract), researchers from the University of Pennsylvania School of Medicine and the National Institutes of Health Reproductive Medicine research network report their findings from a study comparing the pregnancy and live birth rates in women with PCOS using clomiphene (clomid), metformin and a combination of both.

Christos Coutifaris, MD, PhD, Director of the Division of Reproductive Endocrinology and Infertility and the principal investigator from Penn. is quoted as having said that he recommends and supports the use of clomiphene alone and not combined with Metformin as a first-line therapy for infertility in women with PCOS.

The study included 626 infertile women with PCOS who were divided into three groups. The first group received clomiphene and a placebo. The second received metformin and a placebo, and the third group received both metformin and clomiphene. The women took the medication for up to six months.

  • In the metformin only group, 15 out of 208 women had given birth (7.2%).
  • In the clomiphene only group, 47 out of 209 women had given birth (22.5%).
  • In the combined clomiphene-metformin group, 56 out of 209 women had given birth (26.8%).
The difference in the number of births between the clomiphene only group and the combined clomiphene-metformin group was not statistically significant.

The researchers also found that, compared to the other women in the study, obese women were less likely to conceive during the course of the study and less likely to ovulate in response to metformin.


Leah Goodman said...

Very interesting. Thanks for the information. Are there stats on what happens when there's no treatment at all? Does Metformin make a difference?

I personally got pregnant while on Metformin, but there was a question as to whether my lack of ovulation was caused by PCOS or by high levels of prolactin related to a medication I took.

Anonymous said...

In my case, I was not ovulating due to an illness. I got pregnant on the 3rd month while taking clomid only. My son is now 4 years old. I'm now taking both metformin and clomid to have a second child.

Unknown said...

Hi every one I am telling that There is a lot you can do to prevent or minimize polycystic ovary syndrome and ovarian cysts, even if you were born with a genetic tendency to develop cystic ovaries.You can take a look at her book here:
Dr. Dunne's all about pcos .

Anonymous said...

Hi everyone, Dr. Nancy Dunne has written an interesting article about Avandia and PCOS. She thinks improving the composition of your diet, getting more exercise and controlling chronic stress can go a long ways toward solving your insulin resistance problems and may reduce your dependence on Avandia or Glucophage. You can read her article for more details about women taking Avandia for PCOS.

Anonymous said...

Hi everyone, I hope this post will be relevant in a general way to the topic being discussed. It appears that supplemental vitamin D and calcium may have a normalizing effect on your cycle, and could improve chances of conceiving. In a study at Columbia University, 7 of 13 women were able to normalize their cycle within 2 months. You can see more details about this at the Natural Solutions for PCOS website

Anonymous said...

Hi. I got pregnant with my first child using clomid and metformin, the metformin was making me feel sick so on the sixth round i stoped the metformin and took the clomid only, I got pregnant that cycle. Two days ago I started metformin trying for our second child, I don't remember it making me feel this bad, I feel very sick I am going to stop the metformin again.

Anonymous said...

My name is Holly Lem and i would like to show you my personal experience with Clomid.

I am 28 years old. I got preg first time on my own & miscarried. after a while of trying, my dr put me on clomid. after the first round i got pregnant & miscarried. i decided not to try or think about it at all probably for a 9 months... right around the time baby would be due & then started trying again. after a few months got back on clomid. after 5 months and no pregnancy i'm giving it a rest again. it's to much disappointment. i'm going to give it a try again soon, in the mean time we're keeping our fingers crossed for the old fashioned way to work.

I have experienced some of these side effects-
HOT FLASHES, moody, cry easily, weight gain, headaches etc!!

I hope this information will be useful to others,
Holly Lem