Thursday, September 18, 2008

Male Infertility Q&A

Lately msnbc has been posting interesting articles about infertility.

The one I saw today is questions & answers (answers by Dr. Edmund Sabanegh) about male factor infertility. Most of the answers are brief and at least semi-informative, but his answer to the second question as to whether there is a way to test for infertility in her 14-year-old son conceived with the help of ICSI didn't really answer the question that was asked... Was he recommending that she take her son in to test his y-chromosome for deletions? Or perhaps her husband? And if the problem causing his infertility was a y-chromosome deletion (not that I know what that means) wouldn't it cause the defective sperm not to fertilize the egg?

Another article (also published yesterday) discusses this very issue (fertility of sons of infertile men).


JCK said...

HI Rachel!

When I was going through the infertility trail...I remember that there was some research that showed a greater chance of boys conceived through ICSI to grow up to be infertile themselves. But, that was research from several years ago, so I don't know.

Hugs to you from the States!

Elisabeth said...

Infertility in men sometimes has something to do with nature of their work. Because a lot of times, some works do involve exposure to radiation or inhalation of some hazardous chemicals that over time must have contributed to their losing sperms which makes them unable to impregnate their wives. This is apart from the factors of having some inborn reproductive challenges that result to lesser than the average male sperm count.
Nonetheless, medical science nowadays are so well equipped in terms of technology that can address such a reproductive problems in men.

Geohde said...

Personally, I think that the moresevere the male factor, the more likely a known underlying gentic mutation (such as a y-q microdeletion) will be found.

But I would argue that probably all subfertility is genetic on some level (i.e. genotype has a lot to do with phenotype- although enviromental effects such as infection/radiation/undescended testes/trauma may also contribute)...we just haven't identified all the mutations yet.


Sara said...

A Y microdeletion is what it's called when there is a small bit of DNA missing from the Y chromosome. So some critical info isn't there, and as as result the sperm are imperfect. Since males inherit their Y chromosome from their dad only, such a deletion would be passed on.